By Errol C Friedberg
With a Foreword by means of Sydney Brenner (Nobel laureate in body structure or drugs, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's existence from delivery, in 1926, to the current, with distinct emphasis on his huge, immense medical contributions, together with being the 1st to advance know-how that ended in gene cloning technology. In 1980, Berg got a Nobel Prize in chemistry for this work.
In addition to his contributions within the learn laboratory, Berg orchestrated and oversaw a old assembly at Asilomar, California that headquartered on a threatening controversy surrounding the conception via many of the destructive strength of recombinant DNA know-how. This assembly did a lot to stop this controversy and to install position the rules of recombinant DNA paintings, hence placing fears to rest.
The recombinant DNA controversy used to be a old consequence of the invention of gene cloning. significantly, it represented a paramount instance of clinical foresight and due diligence through the clinical group, instead of by means of regulatory entities within the usa and plenty of different international locations. the final word reputation of gene/DNA cloning ended in a brand new period of recent biology that flourishes to the present.
This ebook is aimed essentially at scientists and people in education. The booklet strives to easily offer info for the overall reader, yet isn't really particularly adapted for a basic analyzing audience.
While many books conceal the recombinant DNA controversy, none have satisfactorily addressed this historical interval and are frequently contradictory concerning the many who is, where's, and why's concerned. also, the good majority of those have been written through non-scientists. This biography of Paul Berg presents entry to various archived letters and files at Stanford college no longer formerly addressed, and to the chronology of occasions as recalled and documented via him, in addition to different key personalities, a lot of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and international struggle II
- Western Reserve University
- Part II:
- Washington college, St. Louis
- Discovering move RNA
- Stanford collage — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — an incredible Breakthrough
- EcoRI restrict Endonuclease — an enormous Breakthrough
- “Coincidence is the observe We Use after we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An ancient assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon learn Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a distinct element of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage matters — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in lifestyles sciences, medication and chemistry and lay public.
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Extra info for A Biography of Paul Berg:The Recombinant DNA Controversy Revisited
A Biography of Paul Berg:The Recombinant DNA Controversy Revisited by Errol C Friedberg