Anticancer Agents from Natural Products, Second Edition - download pdf or read online

By Gordon M. Cragg,David G. I. Kingston,David J. Newman

ISBN-10: 1439813825

ISBN-13: 9781439813829

The method of drug discovery from typical resources has yielded many very important new prescription drugs inaccessible through different routes. in lots of situations the remoted traditional product will not be an efficient drug for any of numerous purposes, however it however could develop into a drug via chemical amendment or have a singular pharmacophore for destiny drug layout. In summarizing the prestige of typical items as melanoma chemotherapeutics, Anticancer brokers from typical items, moment Edition covers the:

  • History of every lined drug—a dialogue of its mechanism on motion, medicinal chemistry, synthesis, and scientific applications

  • Potential for novel drug discovery by using genome mining in addition to destiny advancements in anticancer drug discovery

  • Important biosynthetic ways to "unnatural" typical items

Anticancer brokers from average items, moment Edition discusses how complicated target-oriented synthesis—enabled by means of old advances in methodology—has vastly multiplied the scope of the prospective. This ebook covers the present clinically used anticancer brokers which are both common items or are truly derived from typical product leads. It additionally reports drug applicants presently in scientific improvement because a lot of those can be clinically used medicinal drugs sooner or later.

Examples comprise the medication etoposide and teniposide derived from the lead compound podophyllotoxin; a variety of analogs derived from taxol; topotecan, derived from camptothecin; and the artificial scientific applicants, E7389 and HTI-286, built from the marine leads, halichondrin B and hemiasterlin.

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman

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